This course explains synthesis of complex organic molecules and inorganic coordination compounds, discussing significant methodologies in modern chemical synthesis. Particular attention is given to both the general aspects and illustrative applications, along with the description of recent special techniques, chosen among those aimed to improve efficiency, economy and environmental impact of the process.

The students, upon completion of this course, will be able to:
- Acquire, or consolidate, the strategies for the formation and cleavage of the most common chemical bonds, especially carbon-carbon and carbon-heteroatom;
- Learn the basics of stereo synthesis, asymmetric synthesis and orthogonal groups;
- Understand the most modern techniques for the production of relevant nanomaterials;
- Identify how to design a structurally complex molecule, and propose a stepwise manner for its production.

None

I. Advanced Techniques for Organic Synthesis
1. Retrosynthesis and orthogonal approaches; protecting groups
2. Stereochemistry and asymmetric catalysis
3. Conductive polymers
4. Modification of Fullerenes, Carbon nanotubes, and Graphene
II. Advanced Techniques for Inorganic Synthesis
1. Crystal Field Theory and Transition metals
2. Organometallic complexes of Rh and Ir
3. Organometallic complexes of Ni, Pd, and Pt
4. Catalytic cycles: Heck, Sonogashira, Suzuki, Negishi, Stille reactions
III. Modern Synthetic Techniques and Instruments
1. Microwave and ultrasounds
2. Synthesis in ionic liquids
3. Solid phase synthesis and mechanochemistry
4. Combinatorial chemistry
5. Microfluidic techniques
IV. Advanced Techniques for Materials Science
1. Solvothermal, hydrothermal, and co-precipitation methods
2. Pechini method for luminescent oxides and long-lasting phosphors
3. Nanoparticles doping
4. Synthesis and characterization of Quantum dots

No designated textbook, but class notes and handouts will be provided.

1. C. E. Housecroft, A. G. Sharpe, Inorganic Chemistry (Pearson)
2. V. K. Ahluwalia, Organic Synthesis: Special Techniques (Narosa)
3. B. S. Furniss, Vogel's Textbook of Practical Organic Chemistry (Pearson)
4. R. N. Silverstein, F. X. Webster, Spectrometric Identification of Organic Compounds (Wiley)
5. F. Darvas, Flow Chemistry – Fundamentals (DeGruyter)
6. C. O. Kappe, Practical Microwave Synthesis for Organic Chemists: Strategies, Instruments, and Protocols (Wiley)
7. R. H. Crabtree, The Organometallic Chemistry of the Transition Metals (Wiley)
8. M. Smith, March’s Advanced Organic Chemistry (Wiley)

1. Nature Chemistry
2. Angewandte Chemie International Edition
3. Journal of the American Chemical Society
4. Chemical Reviews

Lecture hours = 15 h
Self-study = 30 h

Teaching and learning methods include lectures, class discussions, tutorials, and presentations to understand the underlining concepts necessary for special synthesis in chemistry, with examples to understand complex topics.

The final grade results from the Final exam (100%). Closed-book examination will be used.
Breakdown of final grades (A to D):
A: The student can demonstrate excellent understanding of the knowledge learned in class.
B+: The student can demonstrate a very good understanding of the knowledge learned in class.
B: The student can understand the basic principles of the knowledge learned in class, and shows overall understanding of all the given topics.
C+: The student shows a fair understanding of the topics presented in the course.
C: The student can understand partially the basic principles of the knowledge learned in class, but meets below average expectation on both acquired knowledge and analysis.
D: The student shows a lack of understanding of the topics presented in the course.